2. Academic Validation
  3. The fast degradation of β-TCP ceramics facilitates healing of bone defects by the combination of BMP-2 and Teriparatide

The fast degradation of β-TCP ceramics facilitates healing of bone defects by the combination of BMP-2 and Teriparatide

  • Biomed Pharmacother. 2019 Apr;112:108578. doi: 10.1016/j.biopha.2019.01.039.
Zhongjie Xie 1,  Deyi Yan 1,  Qiang Zhou 2,  Zongyi Wu 1,  Sheji Weng 1,  Viraj Boodhun 1,  Bingli Bai 1,  Zijian Shen 1,  Jiahao Tang 1,  Liang Chen 1,  Bingzhang Wang 1,  Lei Yang 3
Affiliations

Affiliations

  • 1 Department of Orthopaedics Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, Xueyuan West Road, Lucheng District, Wenzhou, 325000, Zhejiang Province, People's Republic of China.
  • 2 Department of Orthopaedics Surgery, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, No. 75, Jingxiu Road, Lucheng District, Wenzhou, 325000, Zhejiang Province, People's Republic of China.
  • 3 Department of Orthopaedics Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, Xueyuan West Road, Lucheng District, Wenzhou, 325000, Zhejiang Province, People's Republic of China. Electronic address: xzj20170726@163.com.
PMID: 30784943 DOI: 10.1016/j.biopha.2019.01.039
Abstract

Accumulating evidence suggests that the degradation and resorption of calcium phosphate ceramics is always relatively slow, which may inhibit calcium phosphate ceramics' replacement by new bone tissues and the ultimate bone defect repair. Bone morphogenetic proteins (BMPs) and Teriparatide (PTH) are extensively applied in the treatment of bone pathologies, while their effects on the degradation of calcium phosphate ceramics is limited. In this study, we tested the effects of BMP and PTH on degradation of β-tricalcium phosphate (β-TCP) ceramics and bone formation on β-TCP in ovariectomized (OVX) rat models. After establishment of femur defect model on OVX rats, the BMP + PTH group's rats were injected Teriparatide (30 μg/kg) subcutaneous every other day, while rats of control group and group BMP were injected equal-to-group volume sterilized saline water. Twelve weeks after femur surgery, all rats were sacrificed for Micro-CT scanning and histology tests. The results showed that BMP facilitated degradation of β-TCP and new bone formation on β-TCP ceramics. And PTH showed an additional effect on degradation of β-TCP when combined with BMP. In addition, the results explained that PTH promoted the remodeling of the bone callus occurred during repair.

Keywords

BMP; Bone defect; Degradation; Osteogenesis; Osteoporosis; Teriparatide; β-TCP.

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