2. Academic Validation
  3. Mindapyrroles A-C, Pyoluteorin Analogues from a Shipworm-Associated Bacterium

Mindapyrroles A-C, Pyoluteorin Analogues from a Shipworm-Associated Bacterium

  • J Nat Prod. 2019 Apr 26;82(4):1024-1028. doi: 10.1021/acs.jnatprod.8b00979.
Noel M Lacerna 2nd 1,  Bailey W Miller 2,  Albebson L Lim 1,  Jortan O Tun 1,  Jose Miguel D Robes 1,  Mark Jeremiah B Cleofas 1,  Zhenjian Lin 2,  Lilibeth A Salvador-Reyes 1,  Margo G Haygood 2,  Eric W Schmidt 2,  Gisela P Concepcion 1
Affiliations

Affiliations

  • 1 The Marine Science Institute , University of the Philippines , Diliman, Quezon City 1101 , Philippines.
  • 2 Department of Medicinal Chemistry , University of Utah , Salt Lake City , Utah 84112 , United States.
PMID: 30793902 DOI: 10.1021/acs.jnatprod.8b00979
Abstract

Three new pyoluteorin analogues, mindapyrroles A-C (1-3), were purified from Pseudomonas aeruginosa strain 1682U.R.0a.27, a gill-associated bacterium isolated from the tissue homogenate of the giant shipworm Kuphus polythalamius. Mindapyrroles B and C inhibit the growth of multiple pathogenic bacteria, with mindapyrrole B (2) showing the most potent antimicrobial activity and widest selectivity index over mammalian cells. Preliminary structure-activity relationship analysis showed that dimerization of the pyoluteorin moiety through a C-C linkage is detrimental to the antimicrobial activity, but addition of an aerugine unit in the methylene bridge is favorable for both the antimicrobial activity and selectivity index.

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