2. Academic Validation
  3. Exploiting the furo[2,3-b]pyridine core against multidrug-resistant Mycobacterium tuberculosis

Exploiting the furo[2,3-b]pyridine core against multidrug-resistant Mycobacterium tuberculosis

  • Bioorg Med Chem Lett. 2019 Apr 15;29(8):974-977. doi: 10.1016/j.bmcl.2019.02.019.
Fernando Fumagalli 1,  Shaiani Maria Gil de Melo 1,  Camila Maríngolo Ribeiro 2,  Mariana Cristina Solcia 2,  Fernando Rogério Pavan 3,  Flavio da Silva Emery 4
Affiliations

Affiliations

  • 1 Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (FCFRP-USP), Av. do Café, s/n° - Campus Universitário da USP, 14040-903 Ribeirão Preto, SP, Brazil.
  • 2 Department of Biological Sciences, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Rodovia Araraquara-Jaú, km01, s/n, Campos Ville, 14800-903 Araraquara, Brazil.
  • 3 Department of Biological Sciences, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Rodovia Araraquara-Jaú, km01, s/n, Campos Ville, 14800-903 Araraquara, Brazil. Electronic address: fernando.pavan@unesp.br.
  • 4 Department of Biological Sciences, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Rodovia Araraquara-Jaú, km01, s/n, Campos Ville, 14800-903 Araraquara, Brazil. Electronic address: flavioemery@usp.br.
PMID: 30803803 DOI: 10.1016/j.bmcl.2019.02.019
Abstract

Identification of new Antibiotics suitable for the treatment of tuberculosis is required. In addition to selectivity, it is necessary to find new Antibiotics that are effective when the tuberculous mycobacteria are resistant to the available therapies. The furo[2,3-b]pyridine core offers potential for this application. Herein, we have described the screening of our in-house library of furopyridines against Mycobacterium tuberculosis and identified a promising selective bioactive compound against different drug-resistant strains of this mycobacteria. The library of compounds was prepared by a CH amination reaction using mild and metal-free conditions, increasing the available information about the reactivity of furo[2,3-b]pyridine core through this reaction.

Keywords

Antibiotic; CH activation; Furopyridine; Multidrug-resistant; Tuberculosis.

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