2. Academic Validation
  3. CUL7 promotes cancer cell survival through promoting Caspase-8 ubiquitination

CUL7 promotes cancer cell survival through promoting Caspase-8 ubiquitination

  • Int J Cancer. 2019 Sep 1;145(5):1371-1381. doi: 10.1002/ijc.32239.
Yanjie Kong 1 2,  Zehua Wang 1,  Maobo Huang 1,  Zhongmei Zhou 1,  Yi Li 3,  Huilai Miao 4,  Xing Wan 5,  Jian Huang 2,  Xiaoyun Mao 6,  Ceshi Chen 1 2 7
Affiliations

Affiliations

  • 1 Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China.
  • 2 Department of Pathology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
  • 3 State Key Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • 4 Department of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
  • 5 Department of Dermatology, Jingmen No.1 people's Hospital, Jingmen, Hubei, China.
  • 6 Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.
  • 7 Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
PMID: 30807646 DOI: 10.1002/ijc.32239
Abstract

The Cullin 7 (CUL7) gene encodes a member of the cullin family of E3 ubiquitin ligases. Accumulated evidence suggests that CUL7 is oncogenic. However, the mechanism by which CUL7 improves Cancer cell survival has not been fully elucidated. Here, we reported that CUL7 confers anti-apoptotic functions by interacting with Caspase-8. CUL7 prevents Caspase-8 activation by promoting Caspase-8 modification with non-degradative polyubiquitin chains at K215. CUL7 knockdown sensitized Cancer cells to TRAIL-induced Apoptosis in vitro and in nude mice. These results suggest that CUL7 limits extrinsic apoptotic signaling by promoting Caspase-8 ubiquitination.

Keywords

CUL7; Caspase-8; apoptosis; ubiquitination.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-101297
    ≥98.0%, Caspase-8 Inhibitor