2. Academic Validation
  3. Trichothecenes from a Soil-Derived Trichoderma brevicompactum

Trichothecenes from a Soil-Derived Trichoderma brevicompactum

  • J Nat Prod. 2019 Apr 26;82(4):687-693. doi: 10.1021/acs.jnatprod.8b00205.
Saranyoo Klaiklay 1,  Vatcharin Rukachaisirikul 2,  Saowanit Saithong 2,  Souwalak Phongpaichit 3,  Jariya Sakayaroj 4
Affiliations

Affiliations

  • 1 Faculty of Science and Industrial Technology , Prince of Songkla University , Surat Thani Campus, Muang Surat Thani, Surat Thani 84000 , Thailand.
  • 2 Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science , Prince of Songkla University , Hat Yai, Songkhla 90112 , Thailand.
  • 3 Natural Products Research Center of Excellence and Department of Microbiology, Faculty of Science , Prince of Songkla University , Hat Yai, Songkhla 90112 , Thailand.
  • 4 School of Science , Walailak University , Nakhornsithammarat 80161 , Thailand.
PMID: 30860372 DOI: 10.1021/acs.jnatprod.8b00205
Abstract

Six new (1-6), together with seven known (7-13), trichothecenes were isolated from the soil-derived Trichoderma brevicompactum PSU-RSPG27. Their structures were established using spectroscopic data. The structure of 1 was confirmed by X-ray data. Trichodermin (7) exhibited the most potent activity against Plasmodium falciparum (K1 strain) with an IC50 value of 0.1 μM, while Other trichothecenes (1, 8, 9, and 12) were much less active, with IC50 values in the range of 7.1-9.6 μM. Compound 7 displayed activity against noncancerous Vero cells with an IC50 value of 0.4 μM. The remaining compounds showed moderate to weak activity, with IC50 values in the range of 6.9-15.3 μM. Compounds 7 and 12 were active against human oral carcinoma (KB) cells with IC50 values of 2.4 and 3.7 μM, respectively. Additionally, compounds 7 and 12 displayed Antifungal activity against Candida albicans with the respective MIC values of 1 and 2 μg/mL and were active against Cryptococcus neoformans with equal MIC values of 4 μg/mL.

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