2. Academic Validation
  3. Acrotrione: An Oxidized Xanthene from the Roots of Acronychia pubescens

Acrotrione: An Oxidized Xanthene from the Roots of Acronychia pubescens

  • J Nat Prod. 2019 Apr 26;82(4):1019-1023. doi: 10.1021/acs.jnatprod.8b00956.
Luke P Robertson 1 2,  Leonardo Lucantoni 2,  Sandra Duffy 2,  Vicky M Avery 2,  Anthony R Carroll 1 2
Affiliations

Affiliations

  • 1 Environmental Futures Research Institute , Griffith University , Gold Coast Campus , Southport 4222 , Australia.
  • 2 Griffith Institute for Drug Discovery , Griffith University , Nathan Campus , Brisbane 4111 , Australia.
PMID: 30865443 DOI: 10.1021/acs.jnatprod.8b00956
Abstract

A new oxidized xanthene, acrotrione (1), and two known acetophenones (2 and 3) were isolated from a methanol extract of the roots of Acronychia pubescens. The structure of 1 was elucidated on the basis of its (+)-HRESIMS, 2D NMR, and ECD data. Acritrione (1) contains an unusual oxidized furo[2,3- c]xanthene moiety that has not been previously reported. Moderate antiplasmodial activity for these Natural Products against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum was determined with IC50 values ranging from 1.7 to 4.7 μM.

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