2. Academic Validation
  3. Design and synthesis of a hapten for the radioimmunoassay of bupropion

Design and synthesis of a hapten for the radioimmunoassay of bupropion

  • J Pharm Sci. 1986 Apr;75(4):410-2. doi: 10.1002/jps.2600750420.
N B Mehta,  D L Musso
PMID: 3088255 DOI: 10.1002/jps.2600750420
Abstract

The synthesis of a hapten useful in the radioimmunoassay of bupropion is described. Since bupropion has no functional group that can be easily derivatized, a hydroxypropyl group was incorporated into the molecule. Studies in cross-reactivity with possible metabolites required the synthesis of the 4'-hydroxy analogue of bupropion. This synthesis is also described.

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