2. Academic Validation
  3. 4(3H)-Quinazolinone derivatives: Promising antibacterial drug leads

4(3H)-Quinazolinone derivatives: Promising antibacterial drug leads

  • Eur J Med Chem. 2019 May 15:170:157-172. doi: 10.1016/j.ejmech.2019.03.018.
Srikanth Gatadi 1,  T Vasanta Lakshmi 1,  Srinivas Nanduri 2
Affiliations

Affiliations

  • 1 Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India.
  • 2 Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India. Electronic address: nandurisrini92@gmail.com.
PMID: 30884322 DOI: 10.1016/j.ejmech.2019.03.018
Abstract

Emergence of drug resistance has created unmet medical need for the development of new classes of Antibiotics. Discovery of new Antibacterial agents with new mode of action remains a high priority universally. 4(3H)-quinazolinone, a fused nitrogen heterocyclic compound has emerged as a biologically privileged structure, possessing a wide range of biological properties viz. Anticancer, Antibacterial, antitubercular, Antifungal, anti-HIV, anticonvulsant, anti-inflammatory and analgesic activities. Promising Antibacterial properties of quinazolinones have enthused the medicinal chemists to explore and develop this fused heterocyclic system for new Antibacterial agents. Utilization of quinazolinone core for the design and synthesis of new Antibacterial agents has recently gained momentum. This review aims to provide an overview of the structures and Antibacterial activity of various 4(3H)-quinazolinone derivatives covering various aspects of in vitro and in vivo pharmacological activities and structure activity relationships (SARs).

Keywords

4(3H)-Quinazolinone; Antibacterial agents; Cytotoxicity; Drug resistance; Minimum inhibitory concentration; Staphylococcus aureus.

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