2. Academic Validation
  3. Omadacycline: A Newly Approved Antibacterial from the Class of Tetracyclines

Omadacycline: A Newly Approved Antibacterial from the Class of Tetracyclines

  • Pharmaceuticals (Basel). 2019 Apr 21;12(2):63. doi: 10.3390/ph12020063.
Fernando Durães 1 2,  Emília Sousa 3 4
Affiliations

Affiliations

  • 1 Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. fduraes5@gmail.com.
  • 2 CIIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos P, 4450-208 Matosinhos, Portugal. fduraes5@gmail.com.
  • 3 Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. esousa@ff.up.pt.
  • 4 CIIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos P, 4450-208 Matosinhos, Portugal. esousa@ff.up.pt.
PMID: 31010063 DOI: 10.3390/ph12020063
Abstract

Omadacycline (Nuzyra®) is a new aminomethylcycline, approved by the U. S. Food and Drug Administration in 2018, as a tetracycline Antibacterial. It can be used in community-acquired pneumonia and in acute Bacterial skin and skin-structure infections. It was developed and is commercialized by Paratek Pharmaceuticals. It is a semisynthetic compound, derived from minocycline, capable of evading widely distributed efflux and target protection Antibacterial resistance mechanisms and has demonstrated activity in a broad spectrum of bacteria.

Keywords

FDA approved; Omadacycline; aminomethylcycline; antibacterial; protein synthesis inhibitor; tetracycline.

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