2. Academic Validation
  3. CXCL13/CXCR5 signaling axis in cancer

CXCL13/CXCR5 signaling axis in cancer

  • Life Sci. 2019 Jun 15;227:175-186. doi: 10.1016/j.lfs.2019.04.053.
Muzammal Hussain 1,  Dickson Adah 2,  Muqddas Tariq 1,  Yongzhi Lu 3,  Jiancun Zhang 4,  Jinsong Liu 5
Affiliations

Affiliations

  • 1 Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Science Park, Guangzhou 510530, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
  • 2 University of Chinese Academy of Sciences, Beijing 100049, PR China; State Key Laboratory of Respiratory Disease, Center for Infection and Immunity, Guangzhou Institutes of Biomedicine and Heath, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Science Park, Guangzhou 510530, PR China.
  • 3 Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Science Park, Guangzhou 510530, PR China.
  • 4 Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Science Park, Guangzhou 510530, PR China. Electronic address: zhang_jiancun@gibh.ac.cn.
  • 5 Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Science Park, Guangzhou 510530, PR China. Electronic address: liu_jinsong@gibh.ac.cn.
PMID: 31026453 DOI: 10.1016/j.lfs.2019.04.053
Abstract

The tumor microenvironment comprises stromal and tumor cells which interact with each other through complex cross-talks that are mediated by a variety of growth factors, cytokines, and chemokines. The chemokine ligand 13 (CXCL13) and its Chemokine Receptor 5 (CXCR5) are among the key chemotactic factors which play crucial roles in deriving cancer Cell Biology. CXCL13/CXCR5 signaling axis makes pivotal contributions to the development and progression of several human cancers. In this review, we discuss how CXCL13/CXCR5 signaling modulates Cancer cell ability to grow, proliferate, invade, and metastasize. Furthermore, we also discuss the preliminary evidence on context-dependent functioning of this axis within the tumor-immune microenvironment, thus, highlighting its potential dichotomy with respect to Anticancer immunity and Cancer immune-evasion mechanisms. At the end, we briefly shed LIGHT on the therapeutic potential or implications of targeting CXCL13/CXCR5 axis within the tumor microenvironment.

Keywords

CXCL13; CXCR5; Cancer; Immune-evasion; Tumor immunity; Tumor progression.

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