2. Academic Validation
  3. Spongian Diterpenes Including One with a Rearranged Skeleton from the Marine Sponge Spongia officinalis

Spongian Diterpenes Including One with a Rearranged Skeleton from the Marine Sponge Spongia officinalis

  • J Nat Prod. 2019 Jun 28;82(6):1714-1718. doi: 10.1021/acs.jnatprod.9b00270.
Qian Chen 1,  Qiqi Mao 1,  Miao Bao 1,  Yongxiao Mou 1,  Chengyan Fang 1,  Min Zhao 1,  Wei Jiang 2,  Xia Yu 3,  Chaojie Wang 1,  Lishang Dai 1,  Wenfei He 1,  Jianyong Dong 1,  Jianzhang Wu 1,  Pengcheng Yan 1
Affiliations

Affiliations

  • 1 School of Pharmaceutical Sciences , Wenzhou Medical University , Wenzhou , Zhejiang 325035 , People's Republic of China.
  • 2 School of Environmental Science and Engineering , Yangzhou University , Yangzhou , Jiangsu 225127 , People's Republic of China.
  • 3 Xiangya School of Pharmaceutical Sciences , Central South University , Changsha , Hunan 410013 , People's Republic of China.
PMID: 31095383 DOI: 10.1021/acs.jnatprod.9b00270
Abstract

Five new diterpenes, including an unprecedented 5,5,6,6,5-pentacyclic diterpene, sponalactone (1), two new spongian diterpenes, 17- O-acetylepispongiatriol (2) and 17- O-acetylspongiatriol (3), and two new spongian diterpene artifacts, 15α,16α-dimethoxy-15,16-dihydroepispongiatriol (4) and 15α-ethoxyepispongiatriol-16(15 H)-one (5), were isolated from a South China Sea collection of the marine Sponge Spongia officinalis, together with three known analogues (6-8). The structures of the new diterpenes were elucidated by extensive spectroscopic analysis. The absolute configurations were established on the basis of ECD data. Compounds 1-5 and 7 exhibited moderate inhibition against LPS-induced NO production in RAW264.7 macrophages with IC50 values of 12-32 μM.

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