2. Academic Validation
  3. Diketopiperazine-Type Alkaloids from a Deep-Sea-Derived Aspergillus puniceus Fungus and Their Effects on Liver X Receptor α

Diketopiperazine-Type Alkaloids from a Deep-Sea-Derived Aspergillus puniceus Fungus and Their Effects on Liver X Receptor α

  • J Nat Prod. 2019 Jun 28;82(6):1558-1564. doi: 10.1021/acs.jnatprod.9b00055.
Xiao Liang 1 2,  Xuelian Zhang 3,  Xinhua Lu 3,  Zhihui Zheng 3,  Xuan Ma 1,  Shuhua Qi 1
Affiliations

Affiliations

  • 1 CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Institution of South China Sea Ecology and Environmental Engineering , South China Sea Institute of Oceanology, Chinese Academy of Sciences , 164 West Xingang Road , Guangzhou , Guangdong 510301 , People's Republic of China.
  • 2 University of Chinese Academy of Sciences , Beijing 100049 , People's Republic of China.
  • 3 New Drug Research & Development Co., Ltd , North China Pharmaceutical Group Corporation , Shijiazhuang , Hebei 050015 , People's Republic of China.
PMID: 31095389 DOI: 10.1021/acs.jnatprod.9b00055
Abstract

Eight new diketopiperazine-type Alkaloids including four oxepin-containing diketopiperazine-type Alkaloids, oxepinamides H-K (1-4), and four 4-quinazolinone Alkaloids, puniceloids A-D (5-8), together with two known analogues (9 and 10), were isolated from the culture broth extracts of the deep-sea-derived fungus Aspergillus puniceus SCSIO z021. Their structures were elucidated by spectroscopic analyses, and their absolute configurations were determined by Marfey's method along with comparison of their specific rotations and ECD spectra. The absolute configurations of 4 and 5 were further confirmed by a single-crystal X-ray diffraction analysis. Compounds 1-8 showed significant transcriptional activation of liver X receptor α with EC50 values of 1.7-50 μM, and 7 and 8 were the most potent agonists.

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