Effect of β-cyfluthrin (synthetic pyrethroid) on learning, muscular coordination and oxidative stress in Swiss albino mice

The present study was planned to evaluate neurotoxic effects of β-cyfluthrin in female Swiss albino mice. Two doses of β-cyfluthrin, specifically, one-tenth of median lethal dose (LD₅₀) and one-twentieth of LD₅₀, were selected for the study. Open-field behaviour, exploratory behaviour and emotional status were affected, and Animals showed anxiety-like behaviour after β-cyfluthrin administration. Spatial learning was decreased using the Hebb-Wiliams maze. Acetylcholinesterase Enzyme activity significantly decreased in the treated Animals. The administration of β-cyfluthrin caused increased lipid peroxidation (malondialdehyde) and decreased superoxide dismutase, catalase and Glutathione Peroxidase activity in brain tissue. In conclusion, β-cyfluthrin caused neurotoxicity as well as oxidative damage in the brain of Swiss albino mice at the tested dose levels.