Cytotoxic Pregnane Steroidal Glycosides from Chonemorpha megacalyx

J Nat Prod. 2019 Jun 28;82(6):1542-1549. doi: 10.1021/acs.jnatprod.9b00013.

Fang-Yu Yuan ¹, Xiao-Ling Wang ², Tian Wang ¹, Tao Shen ¹, Dongmei Ren ¹, Hongxiang Lou ¹, Xiao-Ning Wang ¹

Affiliations

1 Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences , Shandong University , 44 West Wen-Hua Road , Jinan 250012 , People's Republic of China.
2 The Second Hospital of Shandong University , 247 Bei-Yuan Street , Jinan 250033 , People's Republic of China.

PMID: 31148449 DOI: 10.1021/acs.jnatprod.9b00013

Abstract

Three new C₂₁ pregnane Steroids, chonemorphols A-C (1, 3, and 4), 11 new C₂₁ steroidal glycosides, chonemorphosides A-K (2 and 5-14), and 11 known compounds (15-25) were obtained from the vines and leaves of Chonemorpha megacalyx Pierre. Their structures were established using extensive spectroscopic data. The X-ray crystallographic data of 1 and 3 permitted definition of their absolute configurations. Notably, 1 and 2 possessed an uncommon 6/5/6/5/5-fused steroidal ring system. Compound 7 displayed significant cytotoxicity against several Cancer cell lines with IC₅₀ values of 2.0-3.6 μM.

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