2. Academic Validation
  3. Andrographolide: A natural product template for the generation of structurally and biologically diverse diterpenes

Andrographolide: A natural product template for the generation of structurally and biologically diverse diterpenes

  • Eur J Med Chem. 2019 Aug 15:176:513-533. doi: 10.1016/j.ejmech.2019.05.022.
Sai Giridhar Sarma Kandanur 1,  Nitesh Tamang 1,  Nageswara Rao Golakoti 2,  Srinivas Nanduri 3
Affiliations

Affiliations

  • 1 Department of Chemistry, Sri Sathya Sai Institute of Higher Learning, Prasanthi Nilayam, 515134, Puttaparthi, A.P., India.
  • 2 Department of Chemistry, Sri Sathya Sai Institute of Higher Learning, Prasanthi Nilayam, 515134, Puttaparthi, A.P., India. Electronic address: gnageswararao@sssihl.edu.in.
  • 3 Department of Process Chemistry, National Institute of Pharmaceutical Education and Research, Balanagar, 500037, Hyderabad, Telangana, India. Electronic address: nandurisrini92@gmail.com.
PMID: 31151068 DOI: 10.1016/j.ejmech.2019.05.022
Abstract

From times immemorial, Natural Products have played an important role in the management of human health. Andrographis paniculata, belonging to the family Acanthaceae and its constituents are reported to possess a wide range of biological properties such as anti-cancer, anti-diabetic, anti-inflammatory, anti-bacterial, anti-malarial, anti-hepatitis, anti-HIV, anti-atherosclerosis, hepatoprotective, FXR antagonist, and α-glucosidase inhibition. Andrographolide (1), is identified as the major bioactive constituent of the plant. Promising biological properties of the major constituent Andrographolide (1) along with structural amenability for facile semi-synthetic modifications have led to the generation of structurally diverse bioactive labdane diterpenes by several research groups. The promising biological activities exhibited by these semi-synthetic derivatives have further kindled interest and the continued research is evidenced through publications, patents and could possibly lead to the development of Andrographolide based medicines in future. The present review aims at compiling and discussing various semi-synthetic derivatives of Andrographolide in relation to their biological properties and their mechanisms of action.

Keywords

Andrographis paniculata; Andrographolide; Medicinal properties; Semi-synthetic derivatives.

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