2. Academic Validation
  3. Production of New Antibacterial 4-Hydroxy- α-Pyrones by a Marine Fungus Aspergillus niger Cultivated in Solid Medium

Production of New Antibacterial 4-Hydroxy- α-Pyrones by a Marine Fungus Aspergillus niger Cultivated in Solid Medium

  • Mar Drugs. 2019 Jun 10;17(6):344. doi: 10.3390/md17060344.
Lijian Ding 1,  Lu Ren 2,  Shuang Li 3,  Jingjing Song 4,  Zhiwen Han 5,  Shan He 6,  Shihai Xu 7
Affiliations

Affiliations

  • 1 Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315832, China. dinglijian@nbu.edu.cn.
  • 2 Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315832, China. renlurenlu@163.com.
  • 3 Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315832, China. lishuang9892@163.com.
  • 4 Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315832, China. 13123838771@163.com.
  • 5 Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315832, China. hanzhiwen1999@163.com.
  • 6 Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315832, China. heshan@nbu.edu.cn.
  • 7 Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China. txush@jnu.edu.cn.
PMID: 31185700 DOI: 10.3390/md17060344
Abstract

Four 4-hydroxy-α-pyrones including three new ones named nipyrones A-C (1-3) together with one known analogue germicidin C (4) were discovered from a marine sponge-derived fungus Aspergillus niger cultivated in a solid rice culture. Their structures and absolute configurations were elucidated through a combination of spectroscopic data and electronic circular dichroism (ECD) calculations as well as comparison with literature data. Compounds 1-4 were evaluated for their Antibacterial activities against five pathogenic bacteria (Staphylococcus aureus, Escherichia coli, Bacillus subtilis, methicillin-resistant Staphylococcus aureus, and Mycobacterium tuberculosis). Compound 3 showed promising activity against S. aureus and B. subtilis, with minimum inhibitory concentration (MIC) values of 8 μg/mL and 16 μg/mL, respectively, and displayed weak antitubercular activities against M. tuberculosis, with MIC value of 64 μg/mL, while compounds 1 and 2 exhibited moderate Antibacterial efficacy against four pathogenic bacteria with MIC values of 32-64 μg/mL.

Keywords

ECD; antibacterial; marine fungi; pyrone; sponge.

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