2. Academic Validation
  3. Pyranoflavanones and Pyranochalcones from the Fruits of Amomum tsao-ko

Pyranoflavanones and Pyranochalcones from the Fruits of Amomum tsao-ko

  • J Nat Prod. 2019 Jul 26;82(7):1886-1892. doi: 10.1021/acs.jnatprod.9b00155.
Jun Gu Kim 1,  Hari Jang 1,  Thi Phuong Linh Le 1,  Hye Ryoung Hong 1,  Mi Kyeong Lee 1,  Jin Tae Hong 1,  Dongho Lee 2,  Bang Yeon Hwang 1
Affiliations

Affiliations

  • 1 College of Pharmacy , Chungbuk National University , Cheongju 28610 , Korea.
  • 2 Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology , Korea University , Seoul 02841 , Korea.
PMID: 31244142 DOI: 10.1021/acs.jnatprod.9b00155
Abstract

Eight new geranylated and farnesylated pyranoflavanones (1-8) and two new farnesylated pyranochalcones (9 and 10) were isolated from the methanolic extract of the fruits of Amomum tsao-ko. Their structures were elucidated by extensive analysis of the 1D and 2D NMR spectra and from the HRESIMS, combined with experimental ECD data. All compounds were evaluated for their inhibitory effects on the nitric oxide production against lipopolysaccharide-induced RAW 264.7 macrophages and exhibited IC50 values ranging from 10.6 to 41.5 μM.

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