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  3. 1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview

1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview

  • Bioorg Med Chem. 2019 Aug 15;27(16):3511-3531. doi: 10.1016/j.bmc.2019.07.005.
Khurshed Bozorov 1,  Jiangyu Zhao 2,  Haji A Aisa 3
Affiliations

Affiliations

  • 1 Key Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 40-1 South Beijing Rd, Urumqi 830011, PR China; Institute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan, Mirzo Ulugbek Str. 77, Tashkent 100170, Uzbekistan. Electronic address: khurshedbek@gmail.com.
  • 2 Key Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 40-1 South Beijing Rd, Urumqi 830011, PR China. Electronic address: zhaojy@ms.xjb.ac.cn.
  • 3 Key Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 40-1 South Beijing Rd, Urumqi 830011, PR China. Electronic address: haji@ms.xjb.ac.cn.
PMID: 31300317 DOI: 10.1016/j.bmc.2019.07.005
Abstract

The 1,2,3-triazole ring is a major pharmacophore system among nitrogen-containing heterocycles. These five-membered heterocyclic motifs with three nitrogen heteroatoms can be prepared easily using 'click' chemistry with copper- or ruthenium-catalysed azide-alkyne cycloaddition reactions. Recently, the 'linker' property of 1,2,3-triazoles was demonstrated, and a novel class of 1,2,3-triazole-containing hybrids and conjugates was synthesised and evaluated as lead compounds for diverse biological targets. These lead compounds have been demonstrated as Anticancer, antimicrobial, anti-tubercular, Antiviral, antidiabetic, antimalarial, anti-leishmanial, and neuroprotective agents. The present review summarises advances in lead compounds of 1,2,3-triazole-containing hybrids, conjugates, and their related heterocycles in medicinal chemistry published in 2018. This review will be useful to scientists in research fields of organic synthesis, medicinal chemistry, phytochemistry, and pharmacology.

Keywords

1,2,3-Triazole; Biological activity; Click chemistry; Copper-catalysed 1,3-dipolar cycloaddition (CuAAC); Huisgen azide-alkyne cycloaddition; Lead compounds.

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