Recent advances of analogues of curcumin for treatment of cancer

Eur J Med Chem. 2019 Oct 15:180:524-535. doi: 10.1016/j.ejmech.2019.07.034.

Shijie Zhao ¹, Chao Pi ¹, Yun Ye ², Ling Zhao ³, Yumeng Wei ⁴

Affiliations

1 Department of Pharmaceutics, School of Pharmacy, Southwest Medical University, No. 319, Zhongshan Rd Sanduan, Luzhou, Sichuan, 646000, PR China.
2 Department of Pharmaceutics, School of Pharmacy, Southwest Medical University, No. 319, Zhongshan Rd Sanduan, Luzhou, Sichuan, 646000, PR China; Department of Pharmacy, The Affiliated Hospital, Southwest Medical University, No.25, Taiping Street, Luzhou, Sichuan, 646000, China.
3 Department of Pharmaceutics, School of Pharmacy, Southwest Medical University, No. 319, Zhongshan Rd Sanduan, Luzhou, Sichuan, 646000, PR China. Electronic address: zhaoling-998@163.com.
4 Department of Pharmaceutics, School of Pharmacy, Southwest Medical University, No. 319, Zhongshan Rd Sanduan, Luzhou, Sichuan, 646000, PR China. Electronic address: weiyumeng-268@163.com.

PMID: 31336310 DOI: 10.1016/j.ejmech.2019.07.034

Abstract

Curcumin (CU), an edible natural pigment from Curcuma Longa, has demonstrated extensive anti-tumor effect in vivo and in vitro. With the property of reversing drug resistance and low toxicity, CU has been considered to develop a new Adjuvant chemotherapy protocol of Cancer. However, the poor stability, solubility, in vivo bioavailability and weak activity of CU greatly limit its clinical application. Therefore, CU analogues have been extensively studied. Starting from the study of natural CU analogues, multiple approaches are being sought to obtain more stable, soluble and effective analogues of CU. This review focuses on the progress of these approaches to more potent CU analogues.

Keywords

Analogues; Anticancer activity; Curcumin; Structural modification.

Name
Email *

	Sorry, but the email address you supplied was invalid.