1. Academic Validation
  2. Antimicrobial drimane - phthalide derivatives from Hypoxylon fendleri BCC32408

Antimicrobial drimane - phthalide derivatives from Hypoxylon fendleri BCC32408

  • Fitoterapia. 2019 Oct;138:104353. doi: 10.1016/j.fitote.2019.104353.
Chakapong Intaraudom 1 Wikorn Punyain 2 Nantiya Bunbamrung 1 Aibrohim Dramae 1 Tanapong Boonruangprapa 1 Pattama Pittayakhajonwut 3
Affiliations

Affiliations

  • 1 National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Thailand Science Park, Phaholyothin Road, Klong Luang, Pathum Thani 12120, Thailand.
  • 2 Department of Chemistry, Faculty of Science, Naresuan University, Phitsanulok 65000, Thailand.
  • 3 National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Thailand Science Park, Phaholyothin Road, Klong Luang, Pathum Thani 12120, Thailand. Electronic address: pattamap@biotec.or.th.
Abstract

Fourteen new compounds including thirteen drimane - phthalide derivatives (fendlerals A - C, fendlerins A - D, fendlerols A - B, fendleric acids A - C, fendlerinine G) and one terphenyl derivative (fendleryl E) along with eight known compounds, fendlerinine A, rickenyls C - D, fendleryls C - D, atromentin, tetramethyl atromentin, and (±)-microsphaerophthalide F, were isolated from the wood fungus Hypoxylon fendleri BCC32408. Compared with the prior work, the results indicated the agitation effect on the production of bioactive drimane - phthalides. The chemical structures were determined based upon spectroscopic analyses and the absolute configurations were verified by comparison of the ECD spectral data with the calculated ECD spectra of the related compounds. Compounds 1-3 exhibited antimicrobial activity against Plasmodium falciparum (IC50 4.15-4.39 μM), Colletotrichum capsici (MIC 6.25-12.5 μg/mL), and Bacillus cereus (MIC 1.56-3.13 μg/mL). All tested compounds displayed broad cytotoxicity against cancerous (MCF-7, KB, and NCI-H187) and non-cancerous (Vero) cells.

Keywords

Antimicrobial; Cytotoxicity; Drimane – phthalides; Hypoxylon; Hypoxylon fendleri.

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