2. Academic Validation
  3. A new isoflavanone from Uraria crinita

A new isoflavanone from Uraria crinita

  • Nat Prod Res. 2021 Jul;35(13):2211-2217. doi: 10.1080/14786419.2019.1667352.
Dao Duc Thien 1,  Trinh Thi Thuy 1 2,  Nguyen Thi Hoang Anh 1 2,  Le Quoc Thang 3,  Tran Duc Dai 4,  Nguyen Hoang Sa 5,  Nguyen Thanh Tam 1 2
Affiliations

Affiliations

  • 1 Natural Products Research Laboratory, Institute of Chemistry, Vietnam Academy of Science and Technology, Ha Noi, Vietnam.
  • 2 Department of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ha Noi, Vietnam.
  • 3 Department of Chemistry, Hue University's College Education, Hue, Vietnam.
  • 4 Department Medicine and Pharmacy, Tan Trao University, Tuyen Quang, Vietnam.
  • 5 Advanced Institute of Materials Science, Ton Duc Thang University, Ho Chi Minh, Vietnam.
PMID: 31544514 DOI: 10.1080/14786419.2019.1667352
Abstract

A new isoflavanone, (3S)-5,7-dihydroxy-2',3',4'-trimethoxy-6,5'-diprenylisoflavanone (1) and eight known compounds including five Flavones (2-6), two Triterpenes (7-8) and a steroid (9) were isolated from the whole plant of Uraria crinita (Leguminosae). The structure of 1 was elucidated by detailed spectroscopic means including IR, HR-ESI-MS, 1D and 2D NMR, and CD data. Compounds 1-9 were evaluated for their cytotoxicity against four human Cancer cell lines KB (mouth epidermal carcinoma), HepG2 (hepatocellular carcinoma), Lu (lung carcinoma) and MCF7 (breast carcinoma). Compound 1 showed cytotoxic activity against the tested cell lines with IC50 values of 33.2, 29.4, 59.6 and 66.8 μM, respectively.

Keywords

(3S)-5,7-dihydroxy-2′,3′,4′-trimethoxy-6,5′-diprenylisoflavanone; Leguminosae; Uraria crinita; cytotoxicity.

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