2. Academic Validation
  3. 1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships

1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships

  • Eur J Med Chem. 2019 Dec 1:183:111700. doi: 10.1016/j.ejmech.2019.111700.
Zhi Xu 1,  Shi-Jia Zhao 2,  Yi Liu 3
Affiliations

Affiliations

  • 1 Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, PR China. Electronic address: chemorgchem@126.com.
  • 2 Wuhan University of Science and Technology, Wuhan, PR China.
  • 3 Wuhan University of Science and Technology, Wuhan, PR China. Electronic address: yiliuchem@whu.edu.cn.
PMID: 31546197 DOI: 10.1016/j.ejmech.2019.111700
Abstract

Anticancer agents are critical for the Cancer treatment, but side effects and the drug resistance associated with the currently used Anticancer agents create an urgent need to explore novel drugs with low side effects and high efficacy. 1,2,3-Triazole is privileged building block in the discovery of new Anticancer agents, and some of its derivatives have already been applied in clinics or under clinical trials for fighting against cancers. Hybrid molecules occupy an important position in Cancer control, and hybridization of 1,2,3-triazole framework with other Anticancer pharmacophores may provide valuable therapeutic intervention for the treatment of Cancer, especially drug-resistant Cancer. This review emphasizes the recent advances in 1,2,3-triazole-containing hybrids with Anticancer potential, covering articles published between 2015 and 2019, and the structure-activity relationships, together with mechanisms of action are also discussed.

Keywords

1,2,3-Triazole; Action mechanism; Anticancer; Hybrid molecules; Structure-activity relationship.

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