2. Academic Validation
  3. Acute and Subacute Toxicity Assessment of Oxyclozanide in Wistar Rats

Acute and Subacute Toxicity Assessment of Oxyclozanide in Wistar Rats

  • Front Vet Sci. 2019 Sep 6;6:294. doi: 10.3389/fvets.2019.00294.
Weiwei Wang 1 2 3,  Zhen Dong 1 2 3,  Jili Zhang 1 2 3,  Xuzheng Zhou 1 2 3,  Xiaojuan Wei 1 2 3,  Fusheng Cheng 1 2 3,  Bing Li 1 2 3,  Jiyu Zhang 1 2 3
Affiliations

Affiliations

  • 1 Key Laboratory of New Animal Drug Project of Gansu Province, Lanzhou, China.
  • 2 Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou, China.
  • 3 Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, China.
PMID: 31552282 DOI: 10.3389/fvets.2019.00294
Abstract

Oxyclozanide is an effective anthelmintic and has shown good properties in other ways including anti-adenovirus, anti-biofilm, Antifungal, and Antibacterial activity. This study aimed to investigate the acute and subacute 28-days repeated dose oral toxicity of an oxyclozanide suspension in Wistar rats. A high oral lethal dose (LD50) of 3,707 mg/kg was observed in the acute toxicity test. During the 28-days time period, no obvious adverse effects or death were detected. Histopathological changes were observed in the heart, liver, and kidney of Animals treated with high dose of oxyclozanide. Based on the hematological parameters, there were no statistical differences between the oxyclozanide-treated group and the control group. For biochemistry assays, ALP, AST, GLU, TBIL, GLO, TG, BUN, UA, LDH, and CK were statistically changed in the treatment groups. These data suggested that the LD50 of oxyclozanide was ~3,707 mg/kg body weight (BW), and the lowest observed adverse effect level (LOAEL) of oxyclozanide was at a dose of 74 mg/kg in rats.

Keywords

acute; oxyclozanide; rats; subacute; toxicity.

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