2. Academic Validation
  3. Constituents from the Leaves of Tetraena mongolica and Their Protective Activity in HEK 293t Cells Damaged by CdCl2

Constituents from the Leaves of Tetraena mongolica and Their Protective Activity in HEK 293t Cells Damaged by CdCl2

  • J Nat Prod. 2019 Oct 25;82(10):2707-2712. doi: 10.1021/acs.jnatprod.9b00212.
Zhi-Gang Wu 1 2,  Wei Wei 1,  Hai-Yan Xu 1,  Lin-Lin Zheng 1 2,  Chao-Mei Ma 1,  Ying-Chun Wang 1
Affiliations

Affiliations

  • 1 State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences , Inner Mongolia University , Hohhot , People's Republic of China 010070.
  • 2 Key Laboratory of Herbage and Endemic Crop Biotechnology, School of Life Sciences , Inner Mongolia University , Hohhot , People's Republic of China 010070.
PMID: 31593459 DOI: 10.1021/acs.jnatprod.9b00212
Abstract

Tetraena mongolica Maxim, a relict originating from the Tertiary Period, is an endemic species of Zygophyllaceae in China. Three new monoterpenoids (1-3), two new Phenols (4, 5) with unusual O-sulfoglucosyl groups, a new flavonoid (6), and nine known compounds were isolated from the leaves of T. mongolica. The structures of these compounds were determined by interpretation of NMR, MS, and ECD data. Some of the isolated compounds showed protective effects on HEK 293t cells damaged by CdCl2, with IC50 values being 55.7 and 80.3 μM for compounds 7 and 8, respectively, at the time point of 48 h after treatment.

Figures