A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis

Science. 2019 Oct 4;366(6461):128-132. doi: 10.1126/science.aay1436.

Aránzazu Gallego-García ^# ¹, Antonio J Monera-Girona ^# ¹, Elena Pajares-Martínez ^# ¹, Eva Bastida-Martínez ¹, Ricardo Pérez-Castaño ¹, Antonio A Iniesta ¹, Marta Fontes ¹, S Padmanabhan ², Montserrat Elías-Arnanz ³

Affiliations

1 Departamento de Genética y Microbiología, Área de Genética (Unidad Asociada al Instituto de Química Física "Rocasolano," Consejo Superior de Investigaciones Científicas), Facultad de Biología, Universidad de Murcia, Murcia 30100, Spain.
2 Instituto de Química Física "Rocasolano," Consejo Superior de Investigaciones Científicas, 28006 Madrid, Spain. melias@um.es.
3 Departamento de Genética y Microbiología, Área de Genética (Unidad Asociada al Instituto de Química Física "Rocasolano," Consejo Superior de Investigaciones Científicas), Facultad de Biología, Universidad de Murcia, Murcia 30100, Spain. melias@um.es.
# Contributed equally.

PMID: 31604315 DOI: 10.1126/science.aay1436

Abstract

Plasmalogens are glycerophospholipids with a hallmark sn-1 vinyl ether bond. These lipids are found in Animals and some bacteria and have proposed membrane organization, signaling, and antioxidant roles. We discovered the plasmanylethanolamine desaturase activity that is essential for vinyl ether bond formation in a Bacterial enzyme, CarF, which is a homolog of the human Enzyme TMEM189. CarF mediates light-induced carotenogenesis in Myxococcus xanthus, and plasmalogens participate in sensing photooxidative stress through singlet oxygen. TMEM189 and Other animal homologs could functionally replace CarF in M. xanthus, and knockout of TMEM189 in a human cell line eliminated plasmalogens. Discovery of the human plasmanylethanolamine desaturase will spur further study of plasmalogen biogenesis, functions, and roles in disease.

Name
Email *

	Sorry, but the email address you supplied was invalid.