2. Academic Validation
  3. Formation of Drug-Participating Catanionic Aggregates for Extended Delivery of Non-Steroidal Anti-Inflammatory Drugs from Contact Lenses

Formation of Drug-Participating Catanionic Aggregates for Extended Delivery of Non-Steroidal Anti-Inflammatory Drugs from Contact Lenses

  • Biomolecules. 2019 Oct 10;9(10):593. doi: 10.3390/biom9100593.
Cesar Torres-Luna 1,  Abdollah Koolivand 2,  Xin Fan 3,  Niti R Agrawal 4,  Naiping Hu 5,  Yuli Zhu 6,  Roman Domszy 7,  Robert M Briber 8,  Nam Sun Wang 9,  Arthur Yang 10
Affiliations

Affiliations

  • 1 Department of Chemical & Biomolecular Engineering, University of Maryland, College Park, MD 20740, USA. cesartorres093@gmail.com.
  • 2 Department of Chemical & Biomolecular Engineering, University of Maryland, College Park, MD 20740, USA. kolivand@umd.edu.
  • 3 Department of Chemical Engineering, Auburn University, Auburn, AL 36849, USA. xzf0004@tigermail.auburn.edu.
  • 4 Department of Chemical & Biomolecular Engineering, University of Maryland, College Park, MD 20740, USA. nitiagr@umd.edu.
  • 5 Lynthera Corporation, 1200 Corporate Blvd., STE 10C, Lancaster, PA 17601, USA. naiping.hu@gmail.com.
  • 6 Department of Chemical & Biomolecular Engineering, University of Maryland, College Park, MD 20740, USA. dwillyu@163.com.
  • 7 Lynthera Corporation, 1200 Corporate Blvd., STE 10C, Lancaster, PA 17601, USA. rcdom@istninc.com.
  • 8 Department of Materials Science and Engineering, University of Maryland, College Park, MD 20740, USA. rbriber@umd.edu.
  • 9 Department of Chemical & Biomolecular Engineering, University of Maryland, College Park, MD 20740, USA. nsw@umd.edu.
  • 10 Lynthera Corporation, 1200 Corporate Blvd., STE 10C, Lancaster, PA 17601, USA. arthur@lynthera.com.
PMID: 31658626 DOI: 10.3390/biom9100593
Abstract

This paper focuses on extending drug release duration from contact lenses by incorporating catanionic aggregates. The aggregates consist of a long-chain cationic surfactant, i.e., cetalkonium chloride (CKC), and an oppositely charged anti-inflammatory amphiphilic drug. We studied three non-steroidal anti-inflammatory (NSAID) drugs with different octanol-water partition coefficients; diclofenac sodium (DFNa), flurbiprofen sodium (FBNa), and naproxen sodium (NPNa). Confirmation of catanionic aggregate formation in solution was determined by steady and dynamic shear rheology measurements. We observed the increased viscosity, shear thinning, and viscoelastic behavior characteristic of wormlike micelles; the rheological data are reasonably well described using a Maxwellian fluid model with a single relaxation time. In vitro release experiments demonstrated that the extension in the drug release time is dependent on the ability of a drug to form viscoelastic catanionic aggregates. Such aggregates retard the diffusive transport of drug molecules from the contact lenses. Our study revealed that the release kinetics depends on the CKC concentration and the alkyl chain length of the cationic surfactant. We demonstrated that more hydrophobic drugs such as diclofenac sodium show a more extended release than less hydrophobic drugs such as naproxen sodium.

Keywords

Maxwell model; NSAID; aggregates; cationic surfactant; contact lenses; controlled release; drug delivery; hydrogel; rheology; wormlike micelles.

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