2. Academic Validation
  3. Trichothecin inhibits invasion and metastasis of colon carcinoma associating with SCD-1-mediated metabolite alteration

Trichothecin inhibits invasion and metastasis of colon carcinoma associating with SCD-1-mediated metabolite alteration

  • Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Feb;1865(2):158540. doi: 10.1016/j.bbalip.2019.158540.
Chaoliang Liao 1,  Min Li 2,  Xiang Li 3,  Namei Li 1,  Xu Zhao 1,  Xiaoyi Wang 1,  Yawen Song 1,  Jing Quan 1,  Can Cheng 1,  Jikai Liu 4,  Ann M Bode 5,  Ya Cao 6,  Xiangjian Luo 7
Affiliations

Affiliations

  • 1 Key Laboratory of Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China; Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan 410078, China; Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Changsha, Hunan 410078, China.
  • 2 Department of Oncology, Nanjing Hospital of Chinese Medicine affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210001, China.
  • 3 Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China.
  • 4 School of Pharmacy, South-central University for Nationalities, Wuhan, Hubei 430074, China.
  • 5 The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
  • 6 Key Laboratory of Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China; Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan 410078, China; Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Changsha, Hunan 410078, China; Molecular Imaging Research Center of Central South University, Changsha 410008, Hunan, China; National Joint Engineering Research Center for Genetic Diagnostics of Infectious Diseases and Cancer, Changsha 410078, China.
  • 7 Key Laboratory of Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China; Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan 410078, China; Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Changsha, Hunan 410078, China; Molecular Imaging Research Center of Central South University, Changsha 410008, Hunan, China. Electronic address: luocsu@csu.edu.cn.
PMID: 31678511 DOI: 10.1016/j.bbalip.2019.158540
Abstract

Lipid metabolic abnormalities have received intensified concerns and increased de novo synthesis of lipids is recognized as a common feature of many human cancers. Nevertheless, the role of lipid metabolism that confers aggressive properties on human cancers still remains to be revealed. Natural compounds represent an abundant pool of agents for the discovery of novel lead compounds. Trichothecin (TCN) is a sesquiterpenoid originating from an endophytic fungus of the herbal plant Maytenus hookeri Loes. Here, we assess the association of stearoyl-CoA desaturase 1 (SCD-1) over-expression with malignant progression of colorectal Cancer (CRC). Based on this association, the effect of TCN on migration and invasion of colon carcinoma cells closely related to the inhibition of SCD-1 is evaluated. We further demonstrate that reduced production of unsaturated fatty acids (FAs) by blocking SCD-1 activity is beneficial for the anti-invasion effect of TCN. The aim of this study was to clarify the mechanistic connection between metabolite alterations induced by metabolic rewiring and the aggressive tumor phenotype and further develop novel pharmacological tools for the intervention of tumor invasion associated with SCD-1-mediated metabolite alterations.

Keywords

Colorectal carcinoma; Invasion and metastasis; Lipid metabolism; SCD-1; Trichothecin; Unsaturated fatty acid.

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