2. Academic Validation
  3. Two new norsesquiterpenoids with estrogenic activity from the stems and leaves of Dioscorea oppositifolia L

Two new norsesquiterpenoids with estrogenic activity from the stems and leaves of Dioscorea oppositifolia L

  • Nat Prod Res. 2021 Sep;35(18):3018-3025. doi: 10.1080/14786419.2019.1684284.
Ying-Jie Ren 1 2,  Yan-Gang Cao 1 2,  Meng-Nan Zeng 1 2,  Bei-Bei Zhang 1 2,  Yan-Ling Liu 1 2,  Meng-Na Wang 1 2,  Yan-Li Zhang 1 2,  Wei-Sheng Feng 1 2,  Xiao-Ke Zheng 1 2
Affiliations

Affiliations

  • 1 School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China.
  • 2 Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P.R. China, Zhengzhou 450046, China.
PMID: 31680553 DOI: 10.1080/14786419.2019.1684284
Abstract

Two new norsesquiterpenoids, dioscopposin A (1) and dioscopposin B (2), as well as 21 known compounds (3-23) were isolated from the stems and leaves of Dioscorea oppositifolia L. Their structures were elucidated by detailed analysis of comprehensive spectroscopic data. The absolute configurations were deduced by the comparison of experimental and calculated electronic circular dichroism spectra. Estrogenic activity of all the isolated compounds were evaluated using MCF-7 cells proliferation assay and compounds 2, 3, 7, 13, 15, 16, 18 and 21 exhibited proliferation activity.

Keywords

Dioscorea oppositifolia L.; Dioscoreaceae; estrogenic activity; norsesquiterpenoids.

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