2. Academic Validation
  3. Effect of Surfagon on Open Field and Elevated Plus Maze Behavior of Gonadectomized and Non-Gonadectomized Male Rats

Effect of Surfagon on Open Field and Elevated Plus Maze Behavior of Gonadectomized and Non-Gonadectomized Male Rats

  • Bull Exp Biol Med. 2019 Nov;168(1):52-54. doi: 10.1007/s10517-019-04644-4.
O O Masalova 1,  S B Kazakova 2,  T N Savateeva-Lyubimova 2,  K V Sivak 2,  N S Sapronov 3,  P D Shabanov 3
Affiliations

Affiliations

  • 1 Institute of Experimental Medicine, Ministry of Health of the Russian Federation, St. Petersburg, Russia. o.o.masalova@gmail.com.
  • 2 Research Institute of Influenza, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
  • 3 Institute of Experimental Medicine, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
PMID: 31741247 DOI: 10.1007/s10517-019-04644-4
Abstract

We studied the effect of gonadotropin-releasing hormone agonist surfagon (2 μg/kg, once, intraperitoneally) on anxious behavior of adult gonadectomized and non-gonadectomized male rats. It was shown that surfagon significantly increased anxiety of both gonadectomized and non-gonadectomized rats in the open-field test and in elevated plus maze.

Keywords

follicle-stimulating; gonadotropin-releasing hormone; hormone; testosterone; anxiety; luteinizing hormone.

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