2. Academic Validation
  3. Cytotoxic Kendomycins Containing the Carbacylic Ansa Scaffold from the Marine-Derived Verrucosispora sp. SCSIO 07399

Cytotoxic Kendomycins Containing the Carbacylic Ansa Scaffold from the Marine-Derived Verrucosispora sp. SCSIO 07399

  • J Nat Prod. 2019 Dec 27;82(12):3366-3371. doi: 10.1021/acs.jnatprod.9b00654.
Shanwen Zhang 1 2,  Qing Xie 3,  Changli Sun 1,  Xin-Peng Tian 1,  Chun Gui 1 2,  Xiangjing Qin 1,  Hua Zhang 3,  Jianhua Ju 1 2
Affiliations

Affiliations

  • 1 CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology , South China Sea Institute of Oceanology, Chinese Academy of Sciences , 164 West Xingang Road , Guangzhou 510301 , People's Republic of China.
  • 2 College of Oceanology , University of Chinese Academy of Sciences , 19 Yuquan Road , Beijing 110039 , People's Republic of China.
  • 3 Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Institute of Laboratory Medicine , Guangdong Medical University , Dongguan 523808 , People's Republic of China.
PMID: 31765156 DOI: 10.1021/acs.jnatprod.9b00654
Abstract

Three new kendomycin analogues, kendomycins B-D (1-3), were discovered from the marine-derived actinomycete Verrucosispora sp. SCSIO 07399. The structures of 1-3 were elucidated using diverse spectroscopic data analyses, X-ray crystallography, and semisynthetic derivatization. In vitro antimicrobial assays revealed that 1-3 all display good Antibacterial activities against six Gram-positive bacteria with MIC values ranging from 0.5 to 8.0 μg/mL. Additionally, 1-3 were found to be moderately cytotoxic against MGC803, A549, HeLa, HepG2, MCF-7, and RKO human tumor cell lines; IC50 values ranged from 2.2 to 44 μM.

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