Dysfunctional missense variant of OAT10/SLC22A13 decreases gout risk and serum uric acid levels

Affiliations

• 1 Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan.
• 2 Graduate School of Information Science and Technology, Hokkaido University, Sapporo, Japan.
• 3 Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan.
• 4 Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Mishima, Japan.
• 5 Laboratory for Mathematics, National Defense Medical College, Tokorozawa, Japan.
• 6 Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, Japan.
• 7 Ryougoku East Gate Clinic, Tokyo, Japan.
• 8 Midorigaoka Hospital, Takatsuki, Japan.
• 9 Division of Nursing, National Defense Medical College, Tokorozawa, Japan.
• 10 Department of Internal Medicine, Self-Defense Forces Central Hospital, Tokyo, Japan.
• 11 Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
• 12 Department of Preventive Medicine and Public Health, National Defense Medical College, Tokorozawa, Japan.
• 13 Genome Medical Science Project (Toyama), National Center for Global Health and Medicine, Tokyo, Japan.
• 14 Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
• 15 Department of Medical Biochemistry, Kurume University School of Medicine, Kurume, Japan.
• 16 Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan hmatsuo@ndmc.ac.jp tappei-tky@umin.ac.jp.
• 17 Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan hmatsuo@ndmc.ac.jp tappei-tky@umin.ac.jp.
• # Contributed equally.