2. Academic Validation
  3. Effect of low-dose Levamlodipine Besylate in the treatment of vascular dementia

Effect of low-dose Levamlodipine Besylate in the treatment of vascular dementia

  • Sci Rep. 2019 Dec 3;9(1):18248. doi: 10.1038/s41598-019-47868-0.
Kai-Xin Yao 1,  Hang Lyu 2,  Mei-Hua Liao 2,  Lin Yang 3,  Yin-Ping Gao 3,  Qi-Bing Liu 4,  Cheng-Kun Wang 2,  Ying-Mei Lu 3,  Guo-Jun Jiang 5,  Feng Han 6,  Ping Wang 7
Affiliations

Affiliations

  • 1 College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China.
  • 2 College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
  • 3 School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang, China.
  • 4 School of Pharmacy, Hainan Medical College, Haikou, China.
  • 5 Department of Pharmacy, Zhejiang Xiaoshan Hospital, Hangzhou, Zhejiang, China. jguojun999@163.com.
  • 6 College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China. changhuahan@zju.edu.cn.
  • 7 College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China. wangping45@zjut.edu.cn.
PMID: 31796756 DOI: 10.1038/s41598-019-47868-0
Abstract

Vascular dementia (VaD) is a complex disorder caused by reduced blood flow in the brain. However, there is no effective pharmacological treatment option available until now. Here, we reported that low-dose levamlodipine besylate could reverse the cognitive impairment in VaD mice model of right unilateral common carotid arteries occlusion (rUCCAO). Oral administration of levamlodipine besylate (0.1 mg/kg) could reduce the latency to find the hidden platform in the MWM test as compared to the vehicle group. Furthermore, vehicle-treated mice revealed reduced phospho-CaMKII (Thr286) levels in the hippocampus, which can be partially restored by levamlodipine besylate (0.1 mg/kg and 0.5 mg/kg) treatment. No significant outcome on microglia and astrocytes were observed following levamlodipine besylate treatment. This data reveal novel findings of the therapeutic potential of low-dose levamlodipine besylate that could considerably enhance the cognitive function in VaD mice.

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