2. Academic Validation
  3. Cytotoxic 20,22-Dihydrodigitoxigenin Glycosides and Other Constituents of Vallaris glabra Stems

Cytotoxic 20,22-Dihydrodigitoxigenin Glycosides and Other Constituents of Vallaris glabra Stems

  • J Nat Prod. 2019 Dec 27;82(12):3494-3498. doi: 10.1021/acs.jnatprod.9b00803.
Sudarat Kruakaew 1,  Chonticha Seeka 1,  Jantana Yahuafai 2,  Pongpun Siripong 2,  Somyote Sutthivaiyakit 1
Affiliations

Affiliations

  • 1 Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science , Ramkhamhaeng University , Hua Mark, Bangkapi, Bangkok 10240 , Thailand.
  • 2 Natural Products and Integrative Medicine Research Section, Research Division , National Cancer Institute , Rama VI Road , Bangkok 10400 , Thailand.
PMID: 31820973 DOI: 10.1021/acs.jnatprod.9b00803
Abstract

Ten cardiac glycosides (1-10) including six 20,22-dihydrodigitoxigenin and four gitoxigenin glycosides were isolated from the stems of Vallaris glabra together with six known triterpenoid cinnamates. Spectroscopic data of these previously undescribed compounds are reported. All isolates were evaluated for their growth inhibitory activities against three Cancer cell lines, and compound 2 was the most active against KB cells with an IC50 value of 0.03 ± 0.001 μM. Also, compounds 1, 3, 5, and 6 and the triterpenoid cinnamates 11-13 showed inhibitory activity (IC50 < 10 μM) for one or more of the cell lines used.

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