2. Academic Validation
  3. Potential cytotoxic and anti-metastatic effects of berberine on gynaecological cancers with drug-associated resistance

Potential cytotoxic and anti-metastatic effects of berberine on gynaecological cancers with drug-associated resistance

  • Eur J Med Chem. 2020 Feb 1:187:111951. doi: 10.1016/j.ejmech.2019.111951.
Hamed Mortazavi 1,  Banafsheh Nikfar 2,  Seyed-Alireza Esmaeili 3,  Fatemeh Rafieenia 4,  Ehsan Saburi 5,  Shahla Chaichian 6,  Mohammad Ali Heidari Gorji 7,  Amir Abbas Momtazi-Borojeni 8
Affiliations

Affiliations

  • 1 Geriatric Care Research Center, Department of Geriatric Nursing, School of Nursing and Midwifery, North Khorasan University of Medical Sciences, Bojnurd, Iran.
  • 2 Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical Sciences, Tehran, Iran.
  • 3 Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Immunology Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 4 Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 5 Medical Genetics and Molecular Medicine Department, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 6 Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran.
  • 7 Diabetes Research Center, Department of Medical-Surgical Nursing, Nasibeh Faculty of Nursing and Midwifery, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address: heidarianA1@mums.ac.ir.
  • 8 Halal Research Center of IRI, FDA, Tehran, Iran; Nanotechnology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Medical Biotechnology, Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: abbasmomtazi@yahoo.com.
PMID: 31821990 DOI: 10.1016/j.ejmech.2019.111951
Abstract

Gynaecological disorders, such as cervical, ovarian, and endometrial cancers are the second most prevalent Cancer types in women worldwide. Therapeutic approaches for gynaecological cancers involve chemotherapy, radiation, and surgery. However, lifespan is not improved, and novel medications are required. Among various phytochemicals, berberine, a well-known natural product, has been shown to be a promising Cancer chemopreventive agent. Pharmacokinetics, safety, and efficacy of berberine have been investigated in the several experiments against numerous diseases. Here, we aimed to provide a literature review from available published investigations showing the Anticancer effects of berberine and its various synthetic analogues against gynaecological disorders, including cervical, ovarian, and endometrial cancers. In conclusion, berberine has been found to efficiently inhibit viability, proliferation, and migration of Cancer cells, mainly, via induction of Apoptosis by both mitochondrial dependent and -independent pathways. Additionally, structural modification of berberine showed that berberine analogues can improve its antitumor effects against gynaecological cancers.

Keywords

Apoptosis; Berberine; Gynecological cancers.

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