2. Academic Validation
  3. Chemical constituents from Schisandra sphenanthera and their cytotoxic activity

Chemical constituents from Schisandra sphenanthera and their cytotoxic activity

  • Nat Prod Res. 2021 Oct;35(20):3360-3369. doi: 10.1080/14786419.2019.1700247.
Nguyen Thi Mai 1,  Vu Van Doan 2,  Hoang Thi Tuyet Lan 1,  Bui Thi Mai Anh 1,  Nguyen Huy Hoang 2,  Bui Huu Tai 2 3,  Nguyen Xuan Nhiem 2 3,  Pham Hai Yen 2,  Seon Ju Park 4,  Yohan Seo 4,  Wan Namkung 4,  Seung Hyun Kim 4,  Phan Van Kiem 2 3
Affiliations

Affiliations

  • 1 University of Transport and Communications, Ha Noi, Vietnam.
  • 2 Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
  • 3 Graduate University of Science and Technology, VAST, Hanoi, Vietnam.
  • 4 College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University, Incheon, Korea.
PMID: 31829042 DOI: 10.1080/14786419.2019.1700247
Abstract

Extensive phytochemical investigation of Schisandra sphenanthera leaves resulted in the isolation of six highly oxygenated nortriterpenoids (1-6) and five Lignans (7-11) including a new pre-schisanartane-type, schisandrathera A (1), a new dibenzocyclooctadiene glycoside, schisandrathera B (7) and two new Lignans, schisandrathera C (8) and schisandrathera D (9). Their chemical structures including absolute configurations were determined extensively by means of HR-ESI-MS, NMR, and ECD spectra. In addition, all isolated compounds were tested for cytotoxic activity against PC3 (prostate Cancer) and MCF7 (breast Cancer) cell lines. Among these compounds, schirubrisin B (3) showed strong cytotoxic effect on both PC3 and MCF7 cell lines with IC50 values of 3.21 ± 0.68, 13.30 ± 0.68 μM, respectively, whereas ten remaining compounds were found to be less effective in the investigated models.

Keywords

Schisandra sphenanthera; Schisandraceae; schisandrathera A; schisandrathera B; schisandrathera C; schisandrathera D.

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