2. Academic Validation
  3. Antiinflammatory lanostane triterpenoids from Ganoderma lucidum

Antiinflammatory lanostane triterpenoids from Ganoderma lucidum

  • Nat Prod Res. 2021 Nov;35(22):4295-4302. doi: 10.1080/14786419.2019.1705815.
Man Hyung Koo 1,  Hae-Jung Chae 2,  Jun Hyuck Lee 1 3,  Sung-Suk Suh 2,  Ui Joung Youn 3 4
Affiliations

Affiliations

  • 1 Unit of Research for Practical Application, Korea Polar Research Institute, Incheon, Korea.
  • 2 Department of Bioscience, Mokpo National University, Muan, Korea.
  • 3 Department of Polar Sciences, University of Science and Technology, Incheon, South Korea.
  • 4 Division of Life Sciences, Korea Polar Research Institute, KIOST, Incheon, Republic of Korea.
PMID: 31872776 DOI: 10.1080/14786419.2019.1705815
Abstract

Phytochemical and biological studies of the methanolic extracts from Ganoderma lucidum (Polyporaceae) have led to the identification and isolation of a new lanostane triterpenoid, ganosidone A (1), and its eight known derivatives (2‒9). The structure of new compound was determined by HREIMS, 1 D and 2 D NMR experiments and by comparing the acquired physicochemical data with the published values. All the compounds were evaluated for Cancer chemopreventive potential based on their ability to inhibit nitric oxide (NO) production induced by lipopolysaccharides (LPS) in mouse macrophage RAW 264.7 cells in vitro. Notably, at a concentration of 50 μM, compounds 4 and 7 inhibited NO production by 86.5% and 88.2%, respectively.

Keywords

Ganoderma lucidum; inhibit nitric oxide production; lanostane triterpenoid; polyporaceae.

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