2. Academic Validation
  3. Variegatic acid from the edible mushroom Tylopilus ballouii inhibits TNF-α production and PKCβ1 activity in leukemia cells

Variegatic acid from the edible mushroom Tylopilus ballouii inhibits TNF-α production and PKCβ1 activity in leukemia cells

  • Bioorg Med Chem Lett. 2020 Feb 15;30(4):126886. doi: 10.1016/j.bmcl.2019.126886.
Kouichi Sugaya 1,  Mutsumi Ino 1,  Naoki Matsuo 1,  Jun-Ichi Onose 2,  Naoki Abe 3
Affiliations

Affiliations

  • 1 Department of Nutritional Science and Food Safety, Faculty of Applied Bio-Science, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.
  • 2 Department of Nutritional Science and Food Safety, Faculty of Applied Bio-Science, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan. Electronic address: j1onose@nodai.ac.jp.
  • 3 Department of Nutritional Science and Food Safety, Faculty of Applied Bio-Science, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan. Electronic address: abe@nodai.ac.jp.
PMID: 31879206 DOI: 10.1016/j.bmcl.2019.126886
Abstract

Variegatic acid, isolated from Tylopilus ballouii dry fruiting bodies, is an inhibitor of β-hexosaminidase release and tumor necrosis factor (TNF)-α secretion from rat basophilic leukemia (RBL-2H3) cells, with IC50 values of 10.4 μM and 16.8 μM, respectively. On the Other hand, it inhibits PKCβ1 activity with an IC50 value of 36.2 μM.

Keywords

Allergy; Chemokine; Inflammatory response; Variegatic acid.

Figures