Quinolizidine alkaloids derivatives from Sophora alopecuroides Linn: Bioactivities, structure-activity relationships and preliminary molecular mechanisms

Eur J Med Chem. 2020 Feb 15:188:111972. doi: 10.1016/j.ejmech.2019.111972.

Yang Li ¹, Guan Wang ¹, Jie Liu ², Liang Ouyang ³

Affiliations

1 State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
2 State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address: liujie2011@scu.edu.cn.
3 State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address: ouyangliang@scu.edu.cn.

PMID: 31884408 DOI: 10.1016/j.ejmech.2019.111972

Abstract

Quinolizidine Alkaloids, as essential active ingredients extracted from Sophora alopecuroides Linn, have been well concerned in the past several decades owing to the unique structural features and numerous pharmacological activities. Quinolizidine Alkaloids consist of matrine, oxymatrine, sophoridine, sophocarpine and aloperine etc. Additionally, Quinolizidine Alkaloids exert various excellent activities, including anti-cancer, anti-inflammation, anti-fibrosis, anti-virus and anti-arrhythmia regulations. In this review, we comprehensively clarify the pharmacological activities of Quinolizidine Alkaloids, as well as the relationship between biological function and structure-activity of substituted Quinolizidine Alkaloids. We believe that biological agents based on the pharmacological functions of Quinolizidine Alkaloids could be well applied in clinical practice.

Keywords

Alkaloids; Drug target; Pharmacological activities; Quinolizidine; Structure-activity relationships.

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