2. Academic Validation
  3. Clerodane Diterpenoids Isolated from the Leaves of Casearia graveolens

Clerodane Diterpenoids Isolated from the Leaves of Casearia graveolens

  • J Nat Prod. 2020 Jan 24;83(1):36-44. doi: 10.1021/acs.jnatprod.9b00515.
Feng Liu 1,  Jun Ma 1,  Zhaoyu Shi 1,  Qi Zhang 1,  Huimei Wang 1,  Dihua Li 2,  Zhaohui Song 3,  Chunyan Wang 4,  Jin Jin 1,  Jing Xu 1 5,  Muhetaer Tuerhong 6,  Munira Abudukeremu 6,  Ling Shuai 1,  Dongho Lee 7,  Yuanqiang Guo 1
Affiliations

Affiliations

  • 1 State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research , Nankai University , Tianjin 300350 , People's Republic of China.
  • 2 Tianjin Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine , Nankai Hospital Affiliated to Nankai University , Tianjin 300100 , People's Republic of China.
  • 3 State Key Laboratory of Core Technology in Innovative Chinese Medicine , Tasly Pharmaceutical Group Co., Ltd. , Tianjin 300410 , People's Republic of China.
  • 4 Tianjin Second People's Hospital , Tianjin 300192 , People's Republic of China.
  • 5 State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources , Guangxi Normal University , Guilin 541004 , People's Republic of China.
  • 6 College of Chemistry and Environmental Sciences , Kashgar University , Kashgar 844000 , People's Republic of China.
  • 7 College of Life Sciences and Biotechnology , Korea University , Seoul 02841 , Republic of Korea.
PMID: 31916761 DOI: 10.1021/acs.jnatprod.9b00515
Abstract

A phytochemical survey aiming to acquire pharmacologically active substances has resulted in the isolation of nine new clerodane Diterpenoids, named graveospenes A-I (1-9), from the leaves of Casearia graveolens. Spectroscopic methods were employed to establish the structures with their absolute configurations being confirmed by ECD data analysis. A biological evaluation was performed, and compound 1 was found to be cytotoxic to both human lung Cancer cells (A549) and human hepatocellular carcinoma cells (HepG2). A mechanism-of-action study on 1 revealed this compound to induce Apoptosis of A549 cells and impede them at the G0/G1 stage.

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