2. Academic Validation
  3. TRAIL-expressing cell membrane nanovesicles as an anti-inflammatory platform for rheumatoid arthritis therapy

TRAIL-expressing cell membrane nanovesicles as an anti-inflammatory platform for rheumatoid arthritis therapy

  • J Control Release. 2020 Apr 10;320:304-313. doi: 10.1016/j.jconrel.2020.01.054.
Yesi Shi 1,  Fengfei Xie 1,  Peishi Rao 2,  Hongyan Qian 3,  Rongjuan Chen 3,  Hu Chen 4,  Dengfeng Li 4,  Dan Mu 4,  Lili Zhang 1,  Peng Lv 4,  Guixiu Shi 5,  Li Zheng 6,  Gang Liu 7
Affiliations

Affiliations

  • 1 Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The first Affiliated Hospital of Guangxi Medical University, Nanning 530021, China; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.
  • 2 State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China; Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen 361102, China.
  • 3 Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen 361102, China.
  • 4 State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.
  • 5 Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen 361102, China. Electronic address: gshi@xmu.edu.cn.
  • 6 Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The first Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. Electronic address: zhengli224@163.com.
  • 7 State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China. Electronic address: gangliu.cmitm@xmu.edu.cn.
PMID: 32004586 DOI: 10.1016/j.jconrel.2020.01.054
Abstract

Rheumatoid arthritis (RA) is one of the most common chronic autoimmune diseases. Although the progress made with current clinical use of biologic disease-modifying antirheumatic drugs (bioDMARDs), the response rate of RA treatment remains ungratified, primarily due to intricacy interactions of multiple inflammatory cytokines and the awkward drug delivery. Thus, it is of great importance to neutralize cytokines and actively deliver therapeutic agents to RA joints for the purpose of promoting in situ activity. Herein, we proposed and validated a nanoparticle-based broad-spectrum anti-inflammatory strategy for RA management by fusing TRAIL-anchored cell membranes onto drug-loaded polymeric cores (TU-NPs), which makes them ideal decoys of inflamed macrophage-targeted biological molecules. Upon intravenous injection of TU-NPs into collagen-induced arthritic mice, the fluorescence/photoacoustic dual-modal imaging revealed higher accumulations and longer retention of TU-NPs in inflamed joints. In vivo therapeutic evaluations suggested that these nanoparticles could neutralize cytokines, suppress synovial inflammation, and provide strong chondroprotection against joint damage by targeting and deep penetration into the inflamed tissues. Overall, our work provides a novel strategy to treat RA with a strong potential for clinical translation.

Keywords

Cell membrane displaying; Nanoparticles; Rheumatoid arthritis; TRAIL; Targeting.

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