2. Academic Validation
  3. Dammarane-type saponins from Gynostemma pentaphyllum and their cytotoxicities

Dammarane-type saponins from Gynostemma pentaphyllum and their cytotoxicities

  • Nat Prod Res. 2021 Nov;35(22):4433-4441. doi: 10.1080/14786419.2020.1723093.
Wei-Ye Cui 1,  Yulian Jin 2,  Hui Liu 1,  Ma-Li Zu 1,  Xin-Fang Zhai 1,  Ce Yang 1,  Yu-Long Gu 1,  Yong Cheng 1,  Xiang-Lan Piao 1
Affiliations

Affiliations

  • 1 Center on Translational Neuroscience and School of Pharmacy, Minzu University of China, Beijing, China.
  • 2 School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China.
PMID: 32037885 DOI: 10.1080/14786419.2020.1723093
Abstract

Heat-processed Gynostemma pentaphyllum has shown strong activity against human lung carcinoma A549 cells. In this study, two dammarane-type saponins together with two known compounds were isolated from the ethanol extract of the heat-processed leaves of G. pentaphyllum. They were identified as 2α,3β,12β-trihydroxydammar-20(22),24-diene-3-O-β-D-glucopyranoside (1, namely damulin E), 2α,3β,12β-trihydroxydammar-20,24-diene-3-O-β-D-glucopyranoside (2, namely damulin F), damulin A (3) and damulin B (4), respectively, using NMR and mass spectra. Damulin E and damulin F showed moderate activity against A549, H1299, T24, SH-SY5Y and K562 cell lines in vitro using CCK-8 assay.

Keywords

Gynostemma pentaphyllum; cytotoxicity; damulin E; damulin F; saponin.

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