2. Academic Validation
  3. Ikoamide, an Antimalarial Lipopeptide from an Okeania sp. Marine Cyanobacterium

Ikoamide, an Antimalarial Lipopeptide from an Okeania sp. Marine Cyanobacterium

  • J Nat Prod. 2020 Feb 28;83(2):481-488. doi: 10.1021/acs.jnatprod.9b01147.
Keitaro Iwasaki 1,  Arihiro Iwasaki 1,  Shimpei Sumimoto 1,  Teruhiko Matsubara 2,  Toshinori Sato 2,  Tomoyoshi Nozaki 3,  Yumiko Saito-Nakano 4,  Kiyotake Suenaga 1
Affiliations

Affiliations

  • 1 Department of Chemistry, Faculty of Science and Technology , Keio University , 3-14-1 Hiyoshi , Kohoku-ku, Yokohama , Kanagawa 223-8522 , Japan.
  • 2 Department of Biosciences and Informatics, Faculty of Science and Technology , Keio University , 3-14-1 Hiyoshi , Kohoku-ku, Yokohama , Kanagawa 223-8522 , Japan.
  • 3 Department of Biomedical Chemistry, Graduate School of Medicine , The University of Tokyo , 7-3-1 Hongo , Bunkyo-ku, Tokyo 113-0033 , Japan.
  • 4 Department of Parasitology , National Institute of Infectious Diseases , 1-23-1 Toyama , Shinjuku-ku, Tokyo 162-8640 , Japan.
PMID: 32040324 DOI: 10.1021/acs.jnatprod.9b01147
Abstract

An antimalarial Lipopeptide, ikoamide, was isolated from an Okeania sp. marine cyanobacterium. Its gross structure was established by spectroscopic analyses, and the absolute configuration was clarified based on a combination of chiral-phase HPLC analyses, spectroscopic analyses, and derivatization reactions. Ikoamide showed strong antimalarial activity with an IC50 value of 0.14 μM without cytotoxicity against human Cancer cell lines at 10 μM.

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