1. Academic Validation
  2. Lanostane triterpenoids with anti-inflammatory activities from Ganoderma lucidum

Lanostane triterpenoids with anti-inflammatory activities from Ganoderma lucidum

  • Phytochemistry. 2020 May;173:112256. doi: 10.1016/j.phytochem.2019.112256.
Hai-Guo Su 1 Xing-Rong Peng 2 Qiang-Qiang Shi 1 Yan-Jie Huang 1 Lin Zhou 2 Ming-Hua Qiu 3
Affiliations

Affiliations

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, 650201, China; University of the Chinese Academy of Science, Beijing, 100049, China.
  • 2 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, 650201, China.
  • 3 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, 650201, China. Electronic address: mhchiu@mail.kib.ac.cn.
Abstract

Ganoderma lucidum is one of the most famous medicinal fungi and is traditional Chinese medicine with various biological activities in Asian countries. To clarify its pharmacodynamic material basis, 15 lanostane triterpenoidswere obtained from the fruiting bodies of G. lucidum, including 8 previously undescribed lanostanoids. Their structures, including absolute configuration, were established based on ultraviolet, infrared, high-resolution electrospray ionisation mass spectrometry, 1D and 2D nuclear magnetic resonance, and X-ray crystallographic analysis. Ganoluciduone A was an unusual octonorlanostane, which was isolated from Ganoderma for the first time. In addition, the anti-inflammatory activities of all isolates were evaluated by observing their inhibitory effects on nitric oxide production in RAW264.7 cells activated by a lipopolysaccharide. Ganoluciduone B exhibited moderate inhibitory activity on nitric oxide production, with an inhibition rate of 45.5% at a concentration of 12.5 μM.

Keywords

Anti-inflammatory activity; Ganoderma lucidum; Ganodermataceae; Lanostane triterpenoids; Octonorlanostane carbon skeleton.

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