2. Academic Validation
  3. Meliponamycins: Antimicrobials from Stingless Bee-Associated Streptomyces sp

Meliponamycins: Antimicrobials from Stingless Bee-Associated Streptomyces sp

  • J Nat Prod. 2020 Mar 27;83(3):610-616. doi: 10.1021/acs.jnatprod.9b01011.
Carla Menegatti 1,  Vitor Bruno Lourenzon 1,  Diego Rodríguez-Hernández 1,  Weilan Gomes da Paixão Melo 1,  Leonardo Luiz Gomes Ferreira 2,  Adriano Defini Andricopulo 2,  Fabio Santos do Nascimento 3,  Mônica Tallarico Pupo 1
Affiliations

Affiliations

  • 1 Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café, s/n, 14040-903, Ribeirão Preto, SP, Brazil.
  • 2 Instituto de Física de São Carlos, Universidade de São Paulo, Avenida João Dagnone, 1100, 13563-120, São Carlos, SP, Brazil.
  • 3 Departamento de Biologia, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Avenida Bandeirantes, 3900, 14040-901, Ribeirão Preto, SP, Brazil.
PMID: 32073851 DOI: 10.1021/acs.jnatprod.9b01011
Abstract

Social insects establish complex interactions with Microorganisms, some of which play defensive roles in colony protection. The important role of pollinators such as the stingless bee Melipona scutellaris in nature encouraged us to pursue efforts to study its associated microbiota. Here we describe the discovery of two novel cyclic hexadepsipeptides, meliponamycin A (1) and meliponamycin B (2), from Streptomyces sp. ICBG1318 isolated from M. scutellaris nurse bees. Their structures were established by interpretation of NMR and MS data, and the absolute configuration of the constituent Amino acids was determined by the advanced Marfey's method. Compounds 1 and 2 showed strong activity against the entomopathogen Paenibacillus larvae and human pathogens Staphylococcus aureus and Leishmania infantum.

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