2. Academic Validation
  3. Antibiotics from basidiomycetes. XXIX: Pilatin, a new antibiotically active marasmane derivative from cultures of Flagelloscypha pilatii agerer

Antibiotics from basidiomycetes. XXIX: Pilatin, a new antibiotically active marasmane derivative from cultures of Flagelloscypha pilatii agerer

  • J Antibiot (Tokyo). 1988 Dec;41(12):1752-7. doi: 10.7164/antibiotics.41.1752.
J Heim 1,  T Anke,  U Mocek,  B Steffan,  W Steglich
Affiliations

Affiliation

  • 1 LB Biotechnologie der Universität, Kaiserslautern, FRG.
PMID: 3209467 DOI: 10.7164/antibiotics.41.1752
Abstract

Pilatin, a new marasmane derivative, was isolated from fermentations of the cyphelloid fungus Flagelloscypha pilatii. Its structure was determined by chemical and physical methods. Pilatin inhibits the growth of bacteria and fungi at concentrations of 5-50 micrograms/ml. The compound is highly cytotoxic. The incorporation of thymidine and uridine into DNA and RNA in Ehrlich carcinoma ascitic cells is strongly inhibited by pilatin. Like marasmic acid pilatin causes frameshift mutations in Salmonella typhimurium TA98.

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