2. Academic Validation
  3. Diterpenoids from the Root Bark of Pinus massoniana and Evaluation of Their Phosphodiesterase Type 4D Inhibitory Activity

Diterpenoids from the Root Bark of Pinus massoniana and Evaluation of Their Phosphodiesterase Type 4D Inhibitory Activity

  • J Nat Prod. 2020 Apr 24;83(4):1229-1237. doi: 10.1021/acs.jnatprod.9b01269.
Yifan Fu 1 2,  Xiaoyu Ding 2 3,  Xianglei Zhang 2 3,  Xingcheng Shao 1 2,  Jihui Zhao 2 3,  Yechun Xu 2 3,  Xiaomin Luo 2 3,  Weimin Zhao 1 2
Affiliations

Affiliations

  • 1 Department of Natural Products Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
  • 2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
  • 3 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
PMID: 32100544 DOI: 10.1021/acs.jnatprod.9b01269
Abstract

Thirty-two Diterpenoids were obtained from the root bark of Pinus massoniana, and, among them, five compounds (pinmassins A-E) were identified as undescribed analogues. Spectroscopic methods, X-ray single-crystal diffraction analysis, and ECD calculations were applied to establish the structure of the new isolates. Pinmassin D (4) and abieta-8,11,13,15-tetraen-18-oic acid (23) showed moderate phosphodiesterase type 4D (PDE4D) inhibitory effects with IC50 values of 2.8 ± 0.18 and 3.3 ± 0.50 μM, respectively, and their binding modes were investigated by a molecular docking study.

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