2. Academic Validation
  3. Antitumor Efficacy of Focused Ultrasound-MFL Nanoparticles Combination Therapy in Mouse Breast Cancer Xenografts

Antitumor Efficacy of Focused Ultrasound-MFL Nanoparticles Combination Therapy in Mouse Breast Cancer Xenografts

  • Materials (Basel). 2020 Mar 2;13(5):1099. doi: 10.3390/ma13051099.
Daehyun Kim 1 2 3,  Junhee Han 4,  So Yeon Park 3,  Heegon Kim 4,  Ji-Ho Park 4,  Hak Jong Lee 1 2 3
Affiliations

Affiliations

  • 1 Department of Nano Science and Technology, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 151-744, Korea.
  • 2 Department of Radiology, Seoul National University Bundang Hospital, 82 Gumi-ro 173, Bundang-gu, Seongnam 13620, Korea.
  • 3 IMGT Co., Ltd., Seongnam 13605, Korea.
  • 4 Department of Bio and Brain Engineering and KAIST Institute for Health Science and Technology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea.
PMID: 32121631 DOI: 10.3390/ma13051099
Abstract

High doses of chemotherapy agents can cause adverse effects. To address this issue, drug-loaded vesicles with minimum drug loss, guided by an external element for precise delivery, are desired. Combinational therapy of both a focused ultrasound-induced Drug Delivery method and membrane fusogenic liposomes (MFLs) as Drug Delivery vehicles can satisfy such premises. In this study, we confirmed that the use of a small quantity of docetaxel-loaded membrane fusogenic liposomes (DTX-MFL) with focused ultrasound can induce better antitumor response in a xenograft mouse model compared to conventional docetaxel monotherapy and DTX-MFL only.

Keywords

cancer; liposome; ultrasound.

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