2. Academic Validation
  3. Isolation, Characterization, and Possible Anti-Alzheimer's Disease Activities of Bisabolane-Type Sesquiterpenoid Derivatives and Phenolics from the Rhizomes of Curcuma longa

Isolation, Characterization, and Possible Anti-Alzheimer's Disease Activities of Bisabolane-Type Sesquiterpenoid Derivatives and Phenolics from the Rhizomes of Curcuma longa

  • Chem Biodivers. 2020 May;17(5):e2000067. doi: 10.1002/cbdv.202000067.
Pei-Qian Wu 1,  Bing Li 1,  Yi-Fan Yu 1,  Pan-Jie Su 1,  Xu Liu 1,  Zong-Ping Zhang 1,  De-Juan Zhi 1,  Feng-Ming Qi 2,  Dong-Qing Fei 1,  Zhan-Xin Zhang 1
Affiliations

Affiliations

  • 1 School of Pharmacy, Lanzhou University, Lanzhou, 730000, P. R. China.
  • 2 State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, P. R. China.
PMID: 32154990 DOI: 10.1002/cbdv.202000067
Abstract

One new bisabolane-type sesquiterpenoid, together with four known bisabolane-type sesquiterpenoid derivatives and seven phenolics, was isolated from the rhizomes of Curcuma longa. Their structures were elucidated by extensive spectroscopic (IR, HR-ESI-MS, and NMR) data analysis. The possible anti-Alzheimer's disease (AD) activities of the isolated compounds were also evaluated using Caenorhabditis elegans AD pathological model, and 1β-hydroxybisabola-2,10-dien-4-one had the highest possible anti-AD activity.

Keywords

Caenorhabditis elegans; Curcuma longa; bisabolane-type sesquiterpenoids; phenolics; possible anti-Alzheimer's disease activities.

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