2. Academic Validation
  3. 6-Deoxy- and 11-Hydroxytolypodiols: Meroterpenoids from the Cyanobacterium HT-58-2

6-Deoxy- and 11-Hydroxytolypodiols: Meroterpenoids from the Cyanobacterium HT-58-2

  • J Nat Prod. 2020 May 22;83(5):1691-1695. doi: 10.1021/acs.jnatprod.9b00844.
Joshua R Gurr 1,  Timothy J O'Donnell 1,  Yuheng Luo 1,  Wesley Y Yoshida 1,  Mary L Hall 2,  Alejandro M S Mayer 2,  Rui Sun 1,  Philip G Williams 1
Affiliations

Affiliations

  • 1 Department of Chemistry, University of Hawaii at Manoa, 2545 McCarthy Mall, Honolulu, Hawaii 96822, United States.
  • 2 Department of Pharmacology, College of Graduate Studies Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, United States.
PMID: 32282204 DOI: 10.1021/acs.jnatprod.9b00844
Abstract

Chemical investigation of cyanobacterial strain HT-58-2, which most closely aligns with the genus Brasilomena, has led to the isolation of two compounds related to tolypodiol. The structures and absolute configuration of 6-deoxytolypodiol (1) and 11-hydroxytolypodiol (2) were elucidated by spectroscopic and spectrometric analysis. While tolypodiol previously showed anti-inflammatory activity in a mouse ear edema assay, only 2 reduced in vitro thromboxane B2 and superoxide anion (O2-) generation from Escherichia coli lipopolysaccharide-activated rat neonatal microglia to any appreciable degree.

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