2. Academic Validation
  3. A medicinal chemistry perspective of drug repositioning: Recent advances and challenges in drug discovery

A medicinal chemistry perspective of drug repositioning: Recent advances and challenges in drug discovery

  • Eur J Med Chem. 2020 Jun 1:195:112275. doi: 10.1016/j.ejmech.2020.112275.
Thanigaimalai Pillaiyar 1,  Sangeetha Meenakshisundaram 2,  Manoj Manickam 3,  Murugesan Sankaranarayanan 4
Affiliations

Affiliations

  • 1 PharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121, Bonn, Germany. Electronic address: thanigai@uni-bonn.de.
  • 2 Department of Chemistry, Sri Krishna College of Engineering and Technology, Coimbatore, Tamil Nadu, India.
  • 3 Department of Chemistry, PSG Institute of Technology and Applied Research, Coimbatore, Tamil Nadu, India.
  • 4 Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Pilani, 333031, Rajasthan, India.
PMID: 32283298 DOI: 10.1016/j.ejmech.2020.112275
Abstract

Drug repurposing is a strategy consisting of finding new indications for already known marketed drugs used in various clinical settings or highly characterized compounds despite they can be failed drugs. Recently, it emerges as an alternative approach for the rapid identification and development of new pharmaceuticals for various rare and complex diseases for which lack the effective drug treatments. The success rate of drugs repurposing approach accounts for approximately 30% of new FDA approved drugs and vaccines in recent years. This review focuses on the status of drugs repurposing approach for various diseases including skin diseases, infective, inflammatory, Cancer, and neurodegenerative diseases. Efforts have been made to provide structural features and mode of actions of drugs.

Keywords

Cancer; Drug discovery; Drug repositioning; Drug reprofiling; Inflammation; Neurodegenerative diseases; Recycling of drugs; Skin diseases.

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